Read this nice piece by Carolina Perdigoto commenting on our recent Hi-C paper during Drosophila zygotic genome activation and the single-cell Hi-C in oocytes and early mouse embryos by the Tachibana-Konwalski laboratory.
Read our latest work on the emergence of chromatin architecture during early development just out in Cell!
Full text available here:
Press release here:
Our latest work with Ralf Adams and Urs Langen on bone endothelial cell specification during development is out in Nature Cell Biology today:
From pluripotency to totipotency
The first results of our collaboration with Maria Elena Torres-Padilla’s lab in Strasbourg see the light today in Nature Structural and Molecular Biology. In this manuscript, we show that the down-regulation of the histone chaperone CAF-1 in embryonic stem cells results in a dramatic increase of 2-cell-like cells in the culture. The resulting cells display many features of early embryonic totipotent cells, such as specific activation of 2-cell embryo gene expression programmes, up-regulation of repetitive elements, and an increased chromatin mobility.
We are looking for PhD students interested in working on computational analyses of chromatin regulation. The deadline for applications is on Sep 1 2014. For more information, please see PhD positions July 2014.